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O4876 Sigma-Aldrich

Oligomycin from Streptomyces diastatochromogenes

≥90% total oligomycins basis (HPLC)

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action,
Quality Level   200
assay   ≥90% total oligomycins basis (HPLC)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
storage temp.   −20°C
InChI   1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
InChI key   MNULEGDCPYONBU-ZUSSGZTJSA-N

Description

General description

Chemical structure: macrolide

Application

Oligomycin from Streptomyces diastatochromogenes is used:
• in the inhibition of mitochondrial ATP production Leigh syndrome (LS) cells.
• in ATP-linked respiration and maximal capacity respiration assay in astrocytes.
• in measurement of oxygen consumption rate (OCR) and extracellular acidification rates in breast cancer cell lines.

Packaging

100, 250 mg in glass bottle

25 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

Oligomycin belongs to the macrolide group of antibiotics. It inhibits mitochondrial ATP-synthase enzyme and phosphoryl group transfer. Oligomycin interacts with ATP synthase subunit-c in the Fo portion and impairs proton transport.

Other Notes

A mixture of oligomycins A, B, and C.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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