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O8757 Sigma-Aldrich

Ofloxacin

fluoroquinolone antibiotic

  • CAS Number 82419-36-1

  • Empirical Formula (Hill Notation) C18H20FN3O4

  • Molecular Weight 361.37

  •  MDL number MFCD00226105

  •  PubChem Substance ID 24278613

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action,
InChI Key   GSDSWSVVBLHKDQ-UHFFFAOYSA-N
solubility   1 M NaOH: soluble 50 mg/mL
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
storage temp.   2-8°C
Gene Information   human ... CSNK2A1(1457), KCNH1(3756)
rat ... Gabra1(29705)

Description

General description

Chemical structure: fluoroquinolone

Application

Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery.

Packaging

1, 10 g in poly bottle

Biochem/physiol Actions

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which haults DNA replication and cell division. Ofloxacin has been shown to convert LytA from the inactive E-form to the active C-form. It is a chiral molecule that inhibits pneumococcal cell wall-degrading virulence factors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
UU8815500

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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