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P0018 Sigma-Aldrich

Pomalidomide

≥98% (HPLC)

Synonym: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3

  • CAS Number 19171-19-8

  • Empirical Formula (Hill Notation) C13H11N3O4

  • Molecular Weight 273.24

  •  MDL number MFCD12756407

  •  PubChem Substance ID 329819974

  •  NACRES NA.77

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Properties

Related Categories Angiogenesis Regulators, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   yellow
solubility   DMSO: ≥14 mg/mL
storage temp.   2-8°C
SMILES string   Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
InChI   1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key   UVSMNLNDYGZFPF-UHFFFAOYSA-N
Gene Information   human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Cytokine Receptors (Tumor Necrosis Receptor Family)

The cytokines and receptors of the Tumor Necrosis Factor (TNF) superfamily serve as an intercellular communication network integrating cellular responses in vertebrates. TNF receptors activate signal...
Keywords: Angiogenesis, Anti-inflammatory agents, Apoptosis, Calcification, Cancer, Cell proliferation, Diseases, Gene expression, Growth factors, Inflammation, Ligands, Transcription, Transduction

Degrader Building Blocks for Targeted Protein Degradation

An emerging strategy in drug discovery to access difficult-to-treat diseases is targeted protein degradation. While traditional small-molecule or antibody drugs may only allow access to ~20% of the p...
Keywords: Bacterial conjugations, Building blocks, Degradations, Diseases, Drug discovery, Ligands, Parallel synthesis

Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

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901494 N-Methylated pomalidomide, ≥98%
901495 Pomalidomide-PEG3-NH2 hydrochloride, ≥95%
901496 Pomalidomide-C6-CO2H, ≥98%
901500 Pomalidomide-C3-CO2H, ≥95%
901504 Pomalidomide-PEG3-CO2H, ≥95%
901516 Pomalidomide-PEG1-NH2 hydrochloride, ≥95%
901513 Pomalidomide-PEG2-NH2 hydrochloride, ≥95%
901523 Pomalidomide-PEG1-Alkyne, ≥98%
901531 Pomalidomide-PEG3-Alkyne, ≥98%
901529 Pomalidomide-PEG2-Alkyne, ≥95%
901527 Pomalidomide-PEG1-CO2H, ≥95%
901526 Pomalidomide-PEG2-CO2H, 95%
901525 Pomalidomide-C9-CO2H, ≥95%
901558 Lenalidomide, ≥95%
901835 Pomalidomide-PEG6-Alkyne
901834 Pomalidomide-PEG5-Alkyne, ≥95%
901833 Pomalidomide-PEG4-Alkyne
901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
901829 Pomalidomide-PEG6-CO2H
901828 Pomalidomide-PEG5-CO2H, ≥98%
901824 Pomalidomide-PEG4-CO2H
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
903434 Pomalidomide-PEG6-butyl azide, ≥95%
903442 Pomalidomide-PEG6-butyl iodide, ≥95%
903833 Pomalidomide-PEG2-azide
903825 Pomalidomide-PEG1-azide
903957 (S,R,S)-AHPC-PEG1-azide
904651 (S,R,S)-AHPC-PEG3-azide, ≥95%
904724 Pomalidomide-PEG2-butyl iodide, ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide, ≥95%
904678 Pomalidomide-PEG3-azide
904686 Pomalidomide-C6-PEG3-butyl azide, ≥95%
904813 (S,R,S)-AHPC-PEG2-azide
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide, ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide, ≥95%
904872 Pomalidomide-PEG2-butyl azide, ≥95%
904864 (S,R,S)-AHPC-PEG6-butyl azide, ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride, ≥95%
913979 Biotin-Thalidomide, ≥95%

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