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P0021 Sigma-Aldrich

Pantoprazole sodium hydrate

≥98% (HPLC)

Synonym: 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate

  • CAS Number 718635-09-7

  • Empirical Formula (Hill Notation) C16H14F2N3O4S · Na · xH2O

  • Molecular Weight 405.35 (anhydrous basis)

  •  PubChem Substance ID 329819976

  •  NACRES NA.77

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   white to off-white
solubility   H2O: ≥20 mg/mL
originator   Novartis
storage temp.   −20°C
SMILES string   O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
InChI   1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
InChI key   CGJRLPRCWSHOFU-UHFFFAOYSA-N
Gene Information   human ... ATP4A(495), ATP4B(496)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.

Pantoprazole is a gastric proton pump inhibitor.

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Epithelial Sodium Channels (ENaCs)

The recently discovered ENaC/degenerin gene family encodes sodium channels involved in various cell functions in metazoans. The subfamilies include the degenerins, which are part of a mechanosensory ...
Keywords: Anti-inflammatory agents, Atomic absorption spectroscopy, Gene expression, Respiratory

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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