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P0046 Sigma

Pyocyanin

from Pseudomonas aeruginosa, ≥98% (HPLC)

Synonym: 5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin

  • CAS Number 85-66-5

  • Empirical Formula (Hill Notation) C13H10N2O

  • Molecular Weight 210.23

  •  MDL number MFCD01794662

  •  PubChem Substance ID 329819996

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
biological source   Pseudomonas aeruginosa
InChI Key   YNCMLFHHXWETLD-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: soluble
  acetone: soluble
  chloroform: soluble
  ethanol: soluble
shipped in   wet ice
storage temp.   −20°C

Description

Preparation Note

For the preparation of an aqueous solution, dissolve pyocyanin in ethanol using 10% of the final required volume and then add distilled water to complete the volume.

Biochem/physiol Actions

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

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Protocols & Articles

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Peer-Reviewed Papers
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References

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