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P0053 Sigma-Aldrich

PGLa

  • CAS Number 102068-15-5

  • Empirical Formula (Hill Notation) C88H162N26O22S

  • Molecular Weight 1968.45

  •  NACRES NA.85

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action,
Quality Level   200
solubility   H2O: 1 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
  fungi
  viruses
storage temp.   2-8°C
InChI   1S/C88H162N26O22S/c1-19-48(9)69(113-78(126)52(13)97-66(117)42-95-72(120)50(11)98-79(127)59(31-23-27-36-91)108-85(133)64(44-115)111-77(125)54(15)100-81(129)61(33-38-137-18)104-65(116)41-93)87(135)101-51(12)73(121)96-43-67(118)105-57(29-21-25-34-89)82(130)114-70(49(10)20-2)88(136)103-55(16)74(122)106-60(32-24-28-37-92)83(131)112-68(47(7)8)86(134)102-56(17)76(124)110-63(40-46(5)6)84(132)107-58(30-22-26-35-90)80(128)99-53(14)75(123)109-62(71(94)119)39-45(3)4/h45-64,68-70,115H,19-44,89-93H2,1-18H3,(H2,94,119)(H,95,120)(H,96,121)(H,97,117)(H,98,127)(H,99,128)(H,100,129)(H,101,135)(H,102,134)(H,103,136)(H,104,116)(H,105,118)(H,106,122)(H,107,132)(H,108,133)(H,109,123)(H,110,124)(H,111,125)(H,112,131)(H,113,126)(H,114,130)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,68-,69-,70-/m0/s1
InChI key   PJRSUKFWFKUDTH-JWDJOUOUSA-N

Description

Amino Acid Sequence

Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2

General description

Chemical structure: peptide

Application

PGLa is a cationic antimicrobial peptide (AMP) originally isolated from frog. It has been shown to have antibacterial,1 antifungal,2 and antiviral,3 activities. It is used to study novel peptide fragments that originate from PGLa and multinucleated gastric mucosal cells of Xenopus laevis.

Biochem/physiol Actions

The precursors of PGLa are caerulein and xenopsin. The mechanism of action of PGLa against Gram-negative bacteria is disruption of the cellular lipid bilayer.4 It is used to induce transmembrane pore formation in lipid bilayers and bacterial cell membranes. It is used in combination with magainin 2 for a synergistic effect.

Other Notes

500ug

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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