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P0270 Sigma

Calmodulin from bovine heart

lyophilized powder, 2,500-10,000 units/mg protein

Synonym: Phosphodiesterase 3′:5′-cyclic nucleotide activator from bovine heart



Related Categories Biochemicals and Reagents, Proteins and Derivatives, Redox More...
form   lyophilized powder
composition   Protein, ≥85% Lowry
storage temp.   −20°C
Gene Information   cow ... CALM3(520277)



This is the protein activator required for the Ca2+ dependent activation of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520.

Biochem/physiol Actions

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.

Preparation Note

Purified by a modification of the procedure of Teo, T.S., et al., J. Biol. Chem., 248, 588 (1973).

Unit Definition

One unit will stimulate 0.008 activated unit of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520, in a 3 mL reaction volume at pH 7.5 and 30 °C, to 50% of the maximum activity of the enzyme when saturated with activator, in the presence of 0.01 mM Ca2+.

Physical form

Lyophilized powder containing buffer salts as imidazole and magnesium sulfate

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

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