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P0376 Sigma-Aldrich

Phenolphthalein β-D-glucuronide sodium salt

β-glucuronidase substrate

Synonym: Phenolphthalein glucuronic acid, Phenolphthalein mono-β-glucosiduronic acid

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Properties

Related Categories β-Glucuronidase (beta-Glucuronidase), Analytical and Industrial Enzymes, Biochemicals and Reagents, Chromogenic, Enzyme Substrates,
Quality Level   200
assay   ≥90% (TLC)
form   powder
solubility   H2O: soluble 5 mg/mL
storage temp.   −20°C
SMILES string   [Na+].O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C([O-])=O)Oc2ccc(cc2)C3(OC(=O)c4ccccc34)c5ccc(O)cc5
InChI   1S/C26H22O10.Na/c27-15-9-5-13(6-10-15)26(18-4-2-1-3-17(18)24(33)36-26)14-7-11-16(12-8-14)34-25-21(30)19(28)20(29)22(35-25)23(31)32;/h1-12,19-22,25,27-30H,(H,31,32);/q;+1/p-1/t19-,20-,21+,22-,25+,26?;/m0./s1
InChI key   GBLJULUMBNYFAK-PDFLYTMFSA-M

Description

Packaging

1 g in poly bottle

25, 100, 250 mg in poly bottle

Biochem/physiol Actions

Phenolphthalein β-D-glucuronide sodium salt is a β glucuronidase substrate. It is biosynthesized from the urine of rabbits to which phenolphthalein has been administered.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Drug Conjugate Analysis

Glucuronidation by the human UDPglucuronosyltransferase (UGT) family of enzymes plays an important role in the metabolic fate of many drugs and other xenobiotics. This biosynthetic reaction also has ...
Robert Gates
Biofiles Volume 6 Article 1
Keywords: Bacterial conjugations, Chromatography, Gas chromatography, High performance liquid chromatography, Immunoassay, Mass spectrometry, Metabolites

Fermentation: Enzymes, Substrates and SCFA

The influence of probiotics on the metabolic activity of intestinal microbiota may be evaulated by detecting bacterial enzymatic activity in fecal samples, specifically β-glucosidase, β-glucuronidase...
Chloe McClanahan
Biofiles Edition 6.2
Keywords: Absorption, Cancer, Carcinogens, Cell proliferation, Chromatography, Enzyme activity, Gas chromatography, Gastrointestinal, High performance liquid chromatography, Metabolites, Prebiotics, Probiotics, Thin layer chromatography

Probiotics and Human Health

At the beginning of the 20th century, probiotics were thought to have a beneficial effect to the host by improving the intestinal microbial balance. Through his studies and observations, the Russian ...
Chloe McClanahan
BioFiles Edition 6.2
Keywords: AGE, Absorption, Adhesion, Amplification, Anaerobic, Antimicrobials, Cancer, Carcinogens, Cell proliferation, Chromatography, Coagulation, Detoxification, Diagnostic, Diseases, Enzyme activity, Fermentation, Gas chromatography, Gastrointestinal, High performance liquid chromatography, Inflammation, Magnetic resonance spectroscopy, Metabolism, Metabolites, Molecular biology, Nucleic acid hybridization, PAGE, Pharmaceutical, Phosphorylations, Polymerase chain reaction, Prebiotics, Probiotics, Reductions, Respiratory, Sequencing, Thin layer chromatography, Titrations

Peer-Reviewed Papers
15

References

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