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P0496 Sigma-Aldrich

Anti-PTX3 antibody produced in rabbit

affinity isolated antibody, ammonium sulfate suspension

Synonym: Anti-AI607804, Anti-LOC682447, Anti-PTX3, Anti-TNFAIP5, Anti-TSG-14, Anti-pentraxin 3

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies for Gene Regulation, Antibodies to Common Transcription Factors,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: suitable
  western blot: suitable
species reactivity   human, rodent
mol wt   antigen 31.8 kDa
form   ammonium sulfate suspension
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
UniProt accession no.   P26022
Gene Information   human ... PTX3(5806)
mouse ... Ptx3(19288)
rat ... Ptx3_mapped(116998)

Description

General description

The PTX3 (pentraxin 3) gene is mapped to human chromosome 3q25.32. The protein is localized in mesenchymal cells, endothelial cells of vascular tissue, fibroblasts, monocytes and granulocytes.

Immunogen

a synthetic peptide corresponding to human PTX3 (amino acids 110-124) conjugated to BSA.

Application

Anti-PTX3 antibody produced in rabbit has been used in immunofluorescence and immunohistochemistry.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

PTX3 (pentraxin 3) is associated with humoral immune response and inflammatory processes, and therefore offers protection against pathogenic antigens. Proinflammatory cytokines, microbes and signals derived from damaged tissue triggers the expression of the gene upon stimulation. It serves as a biomarker for a number of inflammatory vascular and autoimmune disorders, including vasculitis, rheumatoid arthritis, psoriasis, and cardiovascular diseases. PTX3 is involved in tumor progression by participating in proliferation and invasion steps, which were observed in glioma.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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