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  • P0749 - Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit

P0749 Sigma

Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-HERG, Anti-KCNH2



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Ion Channels, Antibodies to Potassium Channels,
species reactivity   human
application(s)   flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 106 cells)
  immunocytochemistry: 1:25
  western blot: 1:200 using HEK-KV11.1 transfected cells
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... KCNH2(3757)
mouse ... Kcnh2(16511)
rat ... Kcnh2(117018)
biological source   rabbit
conjugate   unconjugated



peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

General description

The K+ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K+ channels based on the number of transmembrane domains. The voltage-gated Potassium or Kv channels belong to the 6 TM K+ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. Kv11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in Kv11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. Kv11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel Kv11.1 extracellular antibodies are specific to Kv11.1.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.


Anti-Potassium channel Kv11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of Kv11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles


Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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