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P1034 Sigma-Aldrich

Phenyl isothiocyanate

Sigma Grade, 8.36 M, suitable for solid phase protein sequencing analysis, ≥99% (GC), liquid

Synonym: PITC

  • CAS Number 103-72-0

  • Linear Formula C6H5NCS

  • Molecular Weight 135.19

  •  Beilstein/REAXYS Number 471392

  •  EC Number 203-138-1

  •  MDL number MFCD00004798

  •  PubChem Substance ID 24898144

  •  NACRES NA.31

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Properties

Related Categories Amino Acid Analysis, Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Derivatization Reagents,
Quality Level   100
grade   Sigma Grade
assay   ≥99% (GC)
form   liquid
concentration   8.36 M
refractive index   n20/D 1.6515 (lit.)
bp   218 °C (lit.)
mp   −21 °C (lit.)
density   1.132 g/mL at 20 °C (lit.)
suitability   suitable for solid phase protein sequencing analysis
storage temp.   2-8°C
SMILES string   S=C=Nc1ccccc1
InChI   1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H
InChI key   QKFJKGMPGYROCL-UHFFFAOYSA-N

Description

General description

Phenyl isothiocyanate belongs to the class of aromatic compounds with isothiocyanate groups. It is typically used as a precolumn derivatization agent for the formation of phenylthiocarbamyl amino acids for their subsequent determination using chromatography techniques.

Application

Phenyl isothiocyanate may be used in the polypeptide and protein sequencing at the subpicomole and subnanomole levels, respectively, by applying automated Edman chemistry followed by the analysis using high-performance liquid chromatography (HPLC) technique.

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

Packaging

One mL size packaged in flame sealed amber ampules under argon.
Ten mL size packaged in screw cap amber vials under argon.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2927 8(6.1) / PGII
WGK Germany 
WGK 3
RTECS 
NX9275000
Protocols & Articles
Peer-Reviewed Papers
15

References

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