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P1038 Sigma-Aldrich

Poly(cytidylic-inosinic) acid potassium salt

random copolymer

Synonym: Poly (C,I)

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Description

Application

Poly(cytidylic-inosinic) acid potassium salt has been used:
• in pretreatment to understand Con A-induced hepatitis in mice
• in RNA extraction from hemolymph plasma for qPCR detection assay
• to induce inflammatory changes in liver
• as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells

Packaging

10 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).

Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.

Other Notes

Random copolymer

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TR0175000

Documents

Certificate of Analysis

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What can I use to solubilize Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?
The product is soluble in water at 10 mg/mL.
How large/long a polymer is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?
The average length of this polynucleotide has not been determined.
IsPoly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, single or double stranded?
Product No. P1038 is a single-stranded random co-polymer.
Will Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, work to induce interferon production?
P1038 is a single stranded RNA. For cell activation, synthetic double-stranded RNA is widely used as the ligand of Toll-like receptor 3 (TLR3) in place of what is supposed to be the natural ligand (viral dsRNA). This would be Product No. P9582, a double stranded RNA homopolymer, i.e. Poly(I): Poly(C). This product is widely used by other satisfied customers for cell activation.
Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, product sterile?
Product No. P1038 is not sterile. The product is produced in non-sterile conditions and the level of endotoxin content is not determined.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles
Peer-Reviewed Papers
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References

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