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P154 Sigma-Aldrich

Pinacidil monohydrate

powder

Synonym: (±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
Quality Level   200
form   powder
color   white to beige
solubility   DMSO: 15 mg/mL, clear
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 40 mg/mL
SMILES string   O.CC(N\C(Nc1ccncc1)=N\C#N)C(C)(C)C
InChI   1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
InChI key   AFJCNBBHEVLGCZ-UHFFFAOYSA-N
Gene Information   human ... ABCC9(10060), KCNJ11(3767)
mouse ... Kcnj11(16514)
rat ... Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj5(29713), Kcnj8(25472)

Description

Application

Pinacidil monohydrate has been used:
• in repolarization studies by infusing into left anterior descending artery (LAD)
• to induce ATP-sensitive K+ (KATP) current in ventricular myocytes for electrophysiological studies
• as a KATP opener to treat myocardial cells

Packaging

1 g in poly bottle

100, 500 mg in poly bottle

Biochem/physiol Actions

K+ channel activator; antihypertensive.

Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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