P2443 Sigma-Aldrich

Pluronic® F-127

powder, BioReagent, suitable for cell culture



Related Categories 3D Printing Materials for Research and Development, Amphiphilic Block Copolymers, Biochemicals and Reagents, Biological Detergents, Block Copolymers,
Quality Level   200
description   Non-ionic
  contains 100ppm BHT
product line   BioReagent
form   powder
mol wt   ~12600 g/mol
application(s)   cell culture | mammalian: suitable
CMC   950-1000 ppm (~25°C)
transition temp   cloud point >100  °C
HLB   18 - 23
InChI   1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2



A non-ionic copolymer surfactant qualified for use in insect cell culture applications as an antifoaming agent.

Pluronic® F-127 was used to coat a siliconized coverslip to hold an egg extract in a study. Pluronic F-127 was added to phosphate buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device. A study reports its use as a release vehicle to transport low-dose perivascular lipopolysaccharide (LPS) on mouse vein grafts. PLGA/pluronic F127 may be used to fabricate nerve guidance conduits (NGCs) for regeneration of peripheral nerve. Fabrication of poly (lactide-co-glycolide) (PLGA) — Pluronic F127 glass composites was reported. Pluronic F-127 was used for fluorescent labeling of blood vessels, astrocytes, and neurons.


1 kg in poly bottle

250 g in poly bottle

Legal Information

Pluronic is a registered trademark of BASF

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the molecular weight of Pluronic F-127, Product P2443?
The average molecular weight is 12.6 kDa.
Why has my solution ofPluronic F-127, Product P2443, gelled?
Pluronic F-127 will form gels above 10 °C when used at concentrations of 18-50%. It will re-liquefy when cooled to below 10 °C. The gel should remain stable during autoclaving.
What concentration of Pluronic F-127, Product P2443, should be used in cell culture?
We test Pluronic F-127 in cell culture at 0.1 g/100 ml media (0.1%).The concentration necessary for your cell application may vary.
What can I use to dilute Pluronic F-127, Product P2443?
The Pluronic F-127 is water soluble as stated on the Specification Sheet.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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