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P3075 Sigma-Aldrich

Phenylarsine oxide

≥97%, powder

Synonym: Arzene, Oxophenylarsine, PAO

  • CAS Number 637-03-6

  • Empirical Formula (Hill Notation) C6H5AsO

  • Molecular Weight 168.02

  •  Beilstein/REAXYS Number 2935227

  •  EC Number 211-275-3

  •  MDL number MFCD00001990

  •  PubChem Substance ID 24898387

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Description

General description

Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3465 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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