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P3134 Sigma-Aldrich

Phosphodiesterase I from Crotalus adamanteus venom

Type VI, crude dried venom

Synonym: 5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase

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Description

Application

Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP. Product P3134 is from crude, dried Crotalus adamanteus venom.

Phosphodiesterase I from Crotalus adamanteus venom has been used:
• for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
• as a model for the hydrolysis of prodrugs in phosphodiesterase assay
• as a component in the nucleotide cleavage buffer

Biochem/physiol Actions

Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
SZ5999500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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15

References

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