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P3246 Sigma-Aldrich

Pipamperone dihydrochloride

~99% (HPLC), powder

Synonym: 1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050

  • CAS Number 2448-68-2

  • Empirical Formula (Hill Notation) C21H30N3O2F · 2HCl

  • Molecular Weight 448.40

  •  EC Number 219-507-5

  •  MDL number MFCD00242980

  •  PubChem Substance ID 24724576

  •  NACRES NA.77

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Properties

Related Categories Antagonists, Antagonists - Dopaminergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
assay   ~99% (HPLC)
form   powder
color   white
solubility   H2O: ~50 mg/mL
originator   Johnson & Johnson
storage temp.   room temp
SMILES string   Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
InChI   1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
InChI key   BMXXSXQVMCXGJM-UHFFFAOYSA-N

Description

Application

Pipamperone dihydrochloride may be used:
• as an internal standard in liquid chromatography with coulometric detection
• as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
• as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Packaging

100 mg in poly bottle

Biochem/physiol Actions

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.

D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
DW1060000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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