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P3510 Sigma-Aldrich

Papaverine hydrochloride

powder

Synonym: 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

  • CAS Number 61-25-6

  • Empirical Formula (Hill Notation) C20H21NO4 · HCl

  • Molecular Weight 375.85

  •  Beilstein/REAXYS Number 3921435

  •  EC Number 200-502-1

  •  MDL number MFCD00012745

  •  PubChem Substance ID 24278152

  •  NACRES NA.77

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Properties

Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Cell Biology,
assay   ≥98%
form   powder
color   white
solubility   H2O: 25 mg/mL
SMILES string   COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl
InChI   1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
InChI key   UOTMYNBWXDUBNX-UHFFFAOYSA-N
Gene Information   human ... PDE4B(5142)

Description

General description

Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.

Application

Papaverine hydrochloride has been used:
• in oxygenated Krebs solution for tissue mechanics analysis
• as a vasodilator in heparinized horse serum in tissue uptake technique
• as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat

Packaging

5, 25, 100 g in poly bottle

Biochem/physiol Actions

Papaverine is originally used to resolve male impotence.

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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