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P3556 Sigma-Aldrich

L-α-Phosphatidylcholine

from egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

Synonym: 1,2-Diacyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, L-α-Lecithin, Azolectin, PC

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Properties

Related Categories Biochemicals and Reagents, Glycerophosphocholines, Glycerophospholipids, Lipids
biological source   egg yolk
type   Type XVI-E
assay   ≥99% (TLC)
form   lyophilized powder
storage temp.   −20°C

Description

General description

Phosphatidylcholine belongs to the class of glycerophoshpolipids and contains choline as the head-group. Choline is attached to the glycerol of fatty acids ester-bound to backbone. It is the major phospholipid found in eukaryotic organism.

Application

L-α-Phosphatidylcholine has been used:
• to form a thin lipid film used in Kupffer cell depletion by liposome-encapsulated clodronate
• as a component of assay buffer used in γ-secretase in vitro assay
• in the preparation of substrate mix for its use in HPLC (high performance liquid chromatography) assay of 5-lipoxygenase enzyme activity

Packaging

1 g in glass bottle

25, 100, 500 mg in glass bottle

Biochem/physiol Actions

It also acts as a source of lipid messengers/ bioactive lipids including: lysophosphatidylcholine, diacylglycerol, phosphatidic acid, lysophosphatidylcholine, arachidonic acid and platelet activating factor. Phosphatidylcholine is produced in the liver by the CDP-choline (cytidine diphosphocholine) pathway.

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.

Packaging

Packaged under Argon

Preparation Note

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
OG7565000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

LC/MS Analysis of Phospholipids in Milk on Ascentis® Express HILIC after SPE using Supelclean™ Si, Shotgun HPLC Analysis

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Phospholipids in Milk on Ascentis® Express HILIC after SPE using Supelclean™ Si, Shotgun HPLC Analysis
Keywords: Chromatography, High performance liquid chromatography, Solid phase extractions

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Related Content

Biochemicals

The biochemicals you use in your experiments directly impact the quality and reproducibility of your results. Biochemicals from us are world class products, competitively priced, and backed by superi...
Keywords: Analytical Chemistry, Biochemistry, Biological Buffers, Buffers, Detergents, Materials Science

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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