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  • P3766 - Phorbol 12-myristate 13-acetate 4-O-methyl ether

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P3766 Sigma-Aldrich

Phorbol 12-myristate 13-acetate 4-O-methyl ether

Synonym: MPMA

  • CAS Number 57716-89-9

  • Empirical Formula (Hill Notation) C37H58O8

  • Molecular Weight 630.85

  •  Beilstein/REAXYS Number 6554604

  •  MDL number MFCD00036790

  •  PubChem Substance ID 24898450

  •  NACRES NA.25

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Properties

Quality Level   100
storage temp.   −20°C
SMILES string   CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(OC)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
InChI   1S/C37H58O8/c1-8-9-10-11-12-13-14-15-16-17-18-19-30(40)44-33-25(3)36(42)28(31-34(5,6)37(31,33)45-26(4)39)21-27(23-38)22-35(43-7)29(36)20-24(2)32(35)41/h20-21,25,28-29,31,33,38,42H,8-19,22-23H2,1-7H3/t25-,28+,29-,31-,33-,35-,36-,37-/m1/s1
InChI key   VCWNAJUHTLWQQT-XCHBPHIQSA-N

Description

Biochem/physiol Actions

Weak phorbol ester agonist; very weak inflammatory and tumor promoting agent.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
GZ0591907
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

Peer-Reviewed Papers
15

References

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