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P5057 Sigma-Aldrich

Paromomycin sulfate salt

powder, BioReagent, suitable for cell culture, ≥98%

  • CAS Number 1263-89-4

  • Empirical Formula (Hill Notation) C23H45N5O14 · xH2SO4

  • Molecular Weight 615.63 (free base basis)

  •  Beilstein/REAXYS Number 5715182

  •  PubChem Substance ID 24898585

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Properties

Related Categories Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S,
Quality Level   200
product line   BioReagent
assay   ≥98%
form   powder
potency   ≥675 μg per mg
application(s)   cell culture | mammalian: suitable
solubility   H2O: 50 mg/mL (store stock solution at 2-8°C. Stable at 37°C for 5 days.)
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   room temp
SMILES string   O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
InChI   1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChI key   OYJABWUHUYVDMJ-UDXJMMFXSA-N

Description

General description

Chemical structure: aminoglycoside

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Application

• Paromomycin sulfate salt has been used as a:
• reference compound in antileishmanial activity
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Other Notes

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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