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P5057 Sigma-Aldrich

Paromomycin sulfate salt

powder, BioReagent, suitable for cell culture, ≥98%

  • CAS Number 1263-89-4

  • Empirical Formula (Hill Notation) C23H45N5O14 · xH2SO4

  • Molecular Weight 615.63 (free base basis)

  •  Beilstein Registry Number 5715182

  •  PubChem Substance ID 24898585

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Properties

Related Categories Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S,
InChI Key   OYJABWUHUYVDMJ-UDXJMMFXSA-N
product line   BioReagent
assay   ≥98%
form   powder
potency   ≥675 μg per mg
application(s)   cell culture | mammalian: suitable
solubility   H2O: 50 mg/mL (store stock solution at 2-8°C. Stable at 37°C for 5 days.)
suitability   suitable for cell culture
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria

Description

Application

Paromomycin sulfate salt has been used as a
• reference compound in antileishmanial activity
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

General description

Chemical structure: aminoglycoside

Other Notes

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Peer-Reviewed Papers
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References

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