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P5155 Sigma-Aldrich

D-Pantothenic acid hemicalcium salt

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Synonym: (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5

  • CAS Number 137-08-6

  • Linear Formula HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca

  • Molecular Weight 238.27

  •  Beilstein/REAXYS Number 3769272

  •  EC Number 205-278-9

  •  MDL number MFCD00002766

  •  eCl@ss 34058012

  •  PubChem Substance ID 24898601

  •  NACRES NA.75



Related Categories Agave sisalana, Allium cepa (Onion), Aloe Vera, Biochemicals and Reagents, Cell Biology,
Quality Level   200
biological source   synthetic (organic)
product line   BioReagent
assay   ≥98% (TLC)
form   powder
mol wt   Mw 238.27 g/mol
application(s)   cell culture | insect: suitable
  cell culture | mammalian: suitable
  cell culture | plant: suitable
color   white to off-white
pH   7.0-8 (25 °C, 50 g/L)
solubility   water: soluble 50 mg/mL, clear, colorless
storage temp.   2-8°C
SMILES string   CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
InChI   1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1


General description

Plants and microorganisms, such as Escherichia coli are the major sources of D-pantothenic acid. It is water soluble and quite stable to heating.


D-Pantothenic acid hemicalcium salt has been used:
• as a component of FMX-turbodoma- derived media
• as a supplement in DMEM (Dulbecco′s modified eagle media)/F-12 used for cell proliferation
• as a supplement in preadipocyte media

Precursor in the biosynthesis of coenzyme A.


100, 500 g in poly bottle

Biochem/physiol Actions

Along with coenzyme A (CoA, D-pantothenic acid is a precursor for acyl carrier protein. These are essential cofactors involved in fat, protein and carbohydrate metabolism. It also participates in the formation of acetylcholine neurotransmitter. D-pantothenic acid is considered as a source of nutrition and possesses immune function by mediating antibody formation. The production of cortisone is supported by D-pantothenic acid. It is essential for adrenal gland activity.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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