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P5248 Sigma-Aldrich

Etidronate disodium hydrate

≥97% (NMR), solid

Synonym: Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research,
Quality Level   100
assay   ≥97% (NMR)
form   solid
color   white
mp   >300 °C
solubility   H2O: ≥10 mg/mL
storage temp.   2-8°C
SMILES string   [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI   1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChI key   GWBBVOVXJZATQQ-UHFFFAOYSA-L

Description

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Packaging

10, 100 mg in glass bottle

Biochem/physiol Actions

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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