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P5333 Sigma-Aldrich

Pleiotrophin human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, cell culture tested

Synonym: HARP, HB-GAM, Heparin affinity regulatory peptide, Heparin-binding growth factor, Heparin-binding growth-associated molecule, PTN

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   human
recombinant   expressed in baculovirus infected Sf21 cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
mol wt   predicted mol wt 15.3 kDa
packaging   pkg of 50 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
suitability   cell culture tested
UniProt accession no.   P21246
storage temp.   −20°C
Gene Information   human ... PTN(5764)

Description

General description

Pleiotrophin (PTN) is a multifunctional growth factor. The protein coded by the PTN gene is a member of the heparin-binding cytokines family. This gene is located on human chromosome 7. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). This gene is highly expressed in brain, uterus, gut, muscle, lung and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, tumor cells, fibroblasts, astrocytes and Schwann cells.

Application

PTN is active in growth and development, and has mitogenic and neurite outgrowth activity. The gene for pleiotrophin is highly expressed in brain, uterus, gut, muscle, lung, and skin tissues

Biochem/physiol Actions

Pleiotrophin participates in growth and development. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.

Pleiotrophin may be the first member of a family of developmentally regulated cytokines. It is active in growth and development and the pleiotrophin gene is highly expressed in brain, uterus, gut, muscle, lung, and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, fibroblasts, astrocytes, Schwann cells, and tumor cells. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The activity is measured in culture by the ability to enhance neurite outgrowth of cerebral cortical neurons from rat embryos.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

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Certificate of Origin

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Peer-Reviewed Papers
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References

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