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P6254 Sigma-Aldrich

Prednisone

≥98%

Synonym: 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone

  • CAS Number 53-03-2

  • Empirical Formula (Hill Notation) C21H26O5

  • Molecular Weight 358.43

  •  Beilstein/REAXYS Number 2065301

  •  EC Number 200-160-3

  •  MDL number MFCD00003608

  •  PubChem Substance ID 24898748

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid,
biological source   synthetic
assay   ≥98%
form   powder
application(s)   hematology: suitable
mp   236-238 °C (lit.)
solubility   chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
shipped in   ambient
storage temp.   room temp
SMILES string   O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
InChI   1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChI key   XOFYZVNMUHMLCC-ZPOLXVRWSA-N
Gene Information   human ... NR3C1(2908)

Description

Application

Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.

Packaging

1 g in poly tube

5, 10, 25 g in poly bottle

Biochem/physiol Actions

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TU4154100
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Cortocisteroids in Urine on Discovery® HS F5 after SPE using Discovery® DSC-CN

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cortocisteroids in Urine on Discovery® HS F5 after SPE using Discovery® DSC-CN
Keywords: Calorimetry, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical, Sample preparations, Solid phase extractions

Peer-Reviewed Papers
15

References

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