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P6273 Sigma-Aldrich

2-Propylpentanoic acid

Synonym: Valproic acid

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Properties

Related Categories Antitumor Agents, Application Index, Biochemicals and Reagents, Branched Fatty Acids, Cancer Research,
Quality Level   200
refractive index   n20/D 1.425 (lit.)
bp   220 °C (lit.)
solubility   H2O: slightly soluble
  alcohol: soluble
density   0.9 g/mL at 25 °C (lit.)
SMILES string   CCCC(C(O)=O)CCC
InChI   1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChI key   NIJJYAXOARWZEE-UHFFFAOYSA-N
Gene Information   human ... ALDH5A1(7915), CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)

Description

Application

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Packaging

100 mL in glass bottle

Biochem/physiol Actions

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
YV7875000
Protocols & Articles
Peer-Reviewed Papers
15

References

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