P6500 Sigma


Synonym: α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neurobiology,
bp   194 °C/12 mmHg(lit.)
mp   59-61 °C(lit.)
storage temp.   −20°C


Biochem/physiol Actions

Non-specific CNS stimulant; convulsant.


25, 50, 100 g in poly bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

UN 2811 6.1 / PGIII

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option:
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
How do I solubilize Product P6500, Pentylenetetrazole?
We test the solubility of this compound at a concentration of 50 mg/mL in water.  This information can be found on the product specification sheet located at this link:
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What is the solution stability for Product P6500, Pentylenetetrazole?
We do not have any solution stability information for this product.  It is always best to make a fresh solution. If this is not possible, you can try storing solution in single use aliquots at -20°C.
Can Product P6500, Pentylenetetrazole, be used to induce convulsions?
Pentylenetetrazole induced convulsions have been reported by De Sarro G. et al., in Eur. J. Pharmacol., 368(2-3),149-159 (1999).
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