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P7547 Sigma-Aldrich

Phentolamine hydrochloride

≥98% (TLC), powder

Synonym: 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride, 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride

  • CAS Number 73-05-2

  • Empirical Formula (Hill Notation) C17H19N3O · HCl

  • Molecular Weight 317.81

  •  Beilstein/REAXYS Number 3764617

  •  EC Number 200-793-5

  •  MDL number MFCD00079268

  •  PubChem Substance ID 24898856

  •  NACRES NA.77

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists- Adrenergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   200
assay   ≥98% (TLC)
form   powder
color   white to off-white
solubility   ethanol: 14 mg/mL
  H2O: 20 mg/mL
  H2O: unstable (prepare immediately prior to use)
originator   Novartis
SMILES string   Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI   1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H
InChI key   TUEJFGFQYKDAPM-UHFFFAOYSA-N
Gene Information   human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Packaging

100, 500 mg in glass bottle

Biochem/physiol Actions

α-adrenoceptor antagonist; peripheral vasodilator.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SL0701000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Peer-Reviewed Papers
15

References

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