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P7556 Sigma-Aldrich

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

Synonym: Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex

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Properties

Related Categories Bioactives and Supplements for Stem Cell Expansion, Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience,
Quality Level   200
biological source   synthetic (organic)
product line   BioReagent
assay   ≥65% (HPLC)
form   powder
application(s)   cell culture | mammalian: suitable
solubility   H2O: 25 mg/mL, clear to slightly hazy
shipped in   ambient
storage temp.   room temp
SMILES string   [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
InChI   1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChI key   RJKFOVLPORLFTN-LEKSSAKUSA-N
Gene Information   human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone-Water Soluble has been used:
• for in vitro maturation of oocyte complexes
• as a σ1R antagonist to study its effect on sigma 1 receptor
• to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro

Packaging

100 mg in glass bottle

Biochem/physiol Actions

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Packaging

Package size based on progesterone content

Other Notes

Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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C0926 (2-Hydroxypropyl)-β-cyclodextrin, powder, BioReagent, suitable for cell culture

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