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P8147 Sigma-Aldrich

Platelet-Derived Growth Factor from human platelets

PDGF, 1 μg/vial, lyophilized powder, suitable for cell culture

Synonym: PDGF



Analysis Note

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

Biochem/physiol Actions

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Other Notes

Isolated from human platelets, predominantly containing two covalently linked subunits (A and B).

Physical form

Lyophilized from a 0.2-μm filtered solution in 40% acetonitrile plus 0.1% TFA


PDGF is a chemoattractant for fibroblasts, smooth muscle cells, monocytes and neutrophils. Also, it acts on fibroblasts and other cells that initiate healing and tissue restoration.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Request a Serum Sample

Cell Culture Guide
Protocols & Articles


Cellular Derived Blood Proteins and Enzymes

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Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.1 PDGF elicits multifunctional actions with a variety of cells, i...
Jennifer Fries
BioFiles 2009, 4.5, 20.
Keywords: Atomic absorption spectroscopy, Growth factors, Purification, Type

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Peer-Reviewed Papers


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