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  • P8232 - Anti-P2X7 Purinergic Receptor antibody produced in rabbit

P8232 Sigma

Anti-P2X7 Purinergic Receptor antibody produced in rabbit

affinity isolated antibody, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Ion Channels,
species reactivity   rat, mouse, human
application(s)   western blot: 1:200-1:1,000
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... P2RX7(5027)
mouse ... P2rx7(18439)
rat ... P2rx7(29665)
biological source   rabbit
conjugate   unconjugated



Peptide (C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 Receptor (Accession Q64663). Intracellular, C-terminus.

General description

Purinergic receptor P2X7 is an ATP-gated cation channel. It is expressed in retinal pigmented epithelium and neural retina. The gene encoding this protein is localized on human chromosome 12.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.


Anti-P2X7 Purinergic Receptor antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

Purinergic receptor P2X7 has a role in immunological processes. It has a role during oxidative stress under pathological conditions. The channel is permeable to Na+, Ca2+ and K+. Prolonged activation of the channel under some pathological conditions leads to the passage of large molecules and ultimately cell death. P2X7 may be involved in the release of interleukin-1β (IL-1β) and indirectly initiate an inflammatory cascade.

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