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P8249 Sigma-Aldrich

Pyoverdines−Gallium (III) complex

from Pseudomonas fluorescens, >90% (HPLC)

Synonym: Ga-Pv, Pyoverdines

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
biological source   Pseudomonas fluorescens
assay   >90% (HPLC)
solubility   H2O: ~10 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Physical form

Supplied as a mixture containing mainly the succinic acid (MW=1231), 2-hydroxy glutaramide (MW=1260), and succinamide (MW=1230) forms of pyoverdines, bound to gallium.

Biochem/physiol Actions

Gallium-pyoverdines act as growth inhibitors of both P. fluorescens and P. aeruginosa possibly due to gallium interference with bacterial iron metabolism.

Pyoverdines, also called pseuobactins and pyoverdins, are fluorescent siderophores that have high affinity for iron (1032 M-1), and are synthesized by fluorescent pseudomonads under iron-deficient growth conditions. Pyoverdines were shown to prevent iron toxicity produced by iron overload in hepatocyte cultures and effectively scavenges the hydroxyl and peroxyl radicals. Pyoverdines are effective in acquiring iron from transferrin and lactoferrin. Pyoverdines are also involved in the suppression of pythium-induced damping-off of tomato and promotion of growth in some higher plants.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Milli-Q® Water Purification Solutions
Protocols & Articles
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P8124 Pyoverdines, from Pseudomonas fluorescens, >90% (HPLC)
P8374 Pyoverdines−Fe complex, from Pseudomonas fluorescens, >90% (HPLC)

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