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P8783 Sigma-Aldrich

Progesterone

powder, BioReagent, suitable for cell culture

Synonym: 4-Pregnene-3,20-dione

  • CAS Number 57-83-0

  • Empirical Formula (Hill Notation) C21H30O2

  • Molecular Weight 314.46

  •  Beilstein/REAXYS Number 1915950

  •  EC Number 200-350-6

  •  MDL number MFCD00003658

  •  PubChem Substance ID 24898978

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Properties

Related Categories Bioactives and Supplements for Stem Cell Expansion, Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience,
Quality Level   200
biological source   synthetic (organic)
description   synthesized from materials derived from plant source
product line   BioReagent
assay   ≥99%
form   powder
potency   0.1-20 ng/mL
application(s)   cell culture | mammalian: suitable
mp   128-132 °C (lit.)
solubility   absolute ethanol: 1 mg/mL
storage temp.   room temp
SMILES string   CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI   1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChI key   RJKFOVLPORLFTN-LEKSSAKUSA-N
Gene Information   human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone has been used:
• as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
• to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
• as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Packaging

1, 5, 25 g in glass bottle

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Other Notes

Steroid hormone produced by the corpus luteum.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TW0175000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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