• USA Home
  • P8861 - Pyrrolnitrin from Pseudomonas cepacia

EMAIL THIS PAGE TO A FRIEND
P8861 Sigma-Aldrich

Pyrrolnitrin from Pseudomonas cepacia

≥98% (HPLC), solid

Synonym: 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole

Purchase

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   200
assay   ≥98% (HPLC)
form   solid
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
shipped in   wet ice
storage temp.   −20°C
SMILES string   [O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl
InChI   1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
InChI key   QJBZDBLBQWFTPZ-UHFFFAOYSA-N

Description

Specificity

The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.

Application

Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.

Biochem/physiol Actions

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.

Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
UX9450000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?