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P9256 Sigma-Aldrich

Psychosine from bovine brain

lyophilized powder, ≥98% (TLC)

Synonym: 1-β-D-Galactosylsphingosine

  • CAS Number 2238-90-6

  • Empirical Formula (Hill Notation) C24H47NO7

  • Molecular Weight 461.63

  •  MDL number MFCD00057505

  •  PubChem Substance ID 24899021

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
assay   ≥98% (TLC)
form   lyophilized powder
storage temp.   −20°C
SMILES string   CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
InChI   1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
InChI key   HHJTWTPUPVQKNA-PIIMIWFASA-N

Description

Application

Psychosine has been used as a lipid in lipid-protein overlay binding assay.

Packaging

1 mg in glass bottle

10 mg in poly bottle

Biochem/physiol Actions

Psychosine is a neurotoxic lysosphingolipid and a glycolipid precursor for the synthesis of cerebrosides. It is synthesized from galactosylceramide, phrenosin. Elevated psychosine levels are implicated in Krabbe disease. It mediates demyelination and consequently oligodendrocytes degeneration. Psychosine is also correlated to neurological disease, Globoid cell leukodystrophy (GLD), where in galactosylceramidase (GALC) enzyme deficiency leads to its accumulation.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P9256.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Glycosphingolipids

Glycosphingolipids (sometimes called glycolipids) have been found in lower and higher eukaryotic sources. They are composed of a glycan structure attached to a lipid tail that contains the sphingolip...
Glycobiology Analysis Manual, 2nd Edition
Keywords: Acetylations, Acylations, Cancer, Degradations, Gene expression, Growth factors, High performance liquid chromatography, Hydroxylations, Sulfations, Transduction

Peer-Reviewed Papers
15

References

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