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P9625 Sigma-Aldrich

Phenazine methosulfate

≥90% (UV)

Synonym: 5-Methylphenazinium methyl sulfate, N-Methylphenazonium methyl sulfate, PMS

  • CAS Number 299-11-6

  • Linear Formula C13H11N2 · CH3SO4

  • Molecular Weight 306.34

  •  Beilstein/REAXYS Number 3898869

  •  EC Number 206-072-1

  •  MDL number MFCD00011923

  •  PubChem Substance ID 24899045

  •  NACRES NA.77

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action, Antifungal,
Quality Level   200
assay   ≥90% (UV)
mp   158-160 °C (dec.) (lit.)
λ   0.01 g/L in H2O, 1 cm path
UV absorption   λ: 387.5 nm Amax: ≥90%
Mode of action   DNA synthesis | interferes
  cell membrane | interferes
antibiotic activity spectrum   fungi
storage temp.   −20°C
SMILES string   COS([O-])(=O)=O.C[n+]1c2ccccc2nc3ccccc13
InChI   1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1
InChI key   RXGJTUSBYWCRBK-UHFFFAOYSA-M

Description

General description

Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.

Application

Phenazine methosulfate is used with ascorbic acid to determine nitric oxide reductase activity.
Phenazine methosulfate has been used:
• as a component of succinate dehydrogenase enzyme substrate solution
• to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability
• as a component of complex II histochemistry media

Packaging

1, 5, 10, 25 g in glass bottle

500 mg in glass bottle

Biochem/physiol Actions

Phenazine m ethosulfate (PMS) acts as a good electron acceptor. PMS is reduced non-enzymatically by (nicotinamide adenine dinucleotide) NADH and (nicotinamide adenine dinucleotide phosphate) NADPH.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SG1645000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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