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P9767 Sigma-Aldrich

Sodium palmitate

≥98.5%

Synonym: Hexadecanoic acid sodium salt, Palmitic acid sodium salt

  • CAS Number 408-35-5

  • Linear Formula CH3(CH2)14COONa

  • Molecular Weight 278.41

  •  Beilstein/REAXYS Number 3575882

  •  EC Number 206-988-1

  •  MDL number MFCD00002749

  •  PubChem Substance ID 24899061

  •  NACRES NA.25

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Properties

Related Categories Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology, Fatty Acid Metabolism in Oncogenesis,
Quality Level   200
biological source   plant (palm)
assay   ≥98.5%
form   powder
mp   283-290 °C (lit.)
functional group   ester
shipped in   ambient
storage temp.   2-8°C
SMILES string   [Na+].CCCCCCCCCCCCCCCC([O-])=O
InChI   1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
InChI key   GGXKEBACDBNFAF-UHFFFAOYSA-M

Description

Application

Sodium palmitate (PA) has been used:
• to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
• to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
• as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Packaging

5, 10, 50 g in poly bottle

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I dissolve Sodium palmitate, Product P9767?
We test the solubility in methanol at 50 mg/mL.
How do I dissolve Sodium palmitate, Product P9767?
Sodium palmitate does not dissolve readily in methanol at room temperature.We test the solubility by heating it for up to 15 minutes to get a clear, colorless solution. Note that the boiling point of methanol is approximately 65°C.
How do I store Sodium palmitate, Product P9767, as provided?
This compound is stable for years at 2-8°C.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles

Articles

Fatty Acid Synthesis and Metabolism in Cancer Cells

Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
BioFiles v7 n4
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Oxidations, Phosphorylations

Peer-Reviewed Papers
15

References

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