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PHG0003 Sigma

MES hydrate

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym: 2-(N-Morpholino)ethanesulfonic acid hydrate, 4-Morpholineethanesulfonic acid

  • CAS Number 1266615-59-1

  • Empirical Formula (Hill Notation) C6H13NO4S · xH2O

  • Molecular Weight 195.24 (anhydrous basis)

  •  MDL number MFCD00149409

  •  PubChem Substance ID 329823021

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Properties

Related Categories Biochemicals and Reagents, Biological Buffers, Good’s Buffers, PharmaGrade Buffers
Quality Level   ELITE
biological source   synthetic
grade   Non-Compendial
InChI Key   MIIIXQJBDGSIKL-UHFFFAOYSA-N
product line   PharmaGrade
form   powder
impurities   Endotoxin, microbial, and trace metals; tested
useful pH range   5.5 - 6.7
pKa    6.1
suitability   suitable for cell culture
  suitable for manufacturing use
foreign activity   Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

Description

Application

MES is a biological buffer often referred to as a “Good’s” buffer. The pKa of MES is 5.96 which makes MES an ideal candidate for medias and protein based buffer formulations to maintain a stable environment in solution. MES is considered to be non-toxic to culture cell lines, highly water soluble and provides high-solution clarity.

MES is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream), and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins, blood components and growth factors.

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Linkage

Enhanced Quality Product Documentation on PharmaGrade MES hydrate

Packaging

100 g in poly bottle

5, 25, 50 kg in poly drum

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

High Quality GMP-Buffers

Protein Stabilizer
Protocols & Articles

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Peer-Reviewed Papers
15

References

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