• USA Home
  • PHG0006 - Guanidine hydrochloride

EMAIL THIS PAGE TO A FRIEND
PHG0006 SAFC

Guanidine hydrochloride

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.

Synonym: Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

  • CAS Number 50-01-1

  • Linear Formula NH2C(=NH)NH2 · HCl

  • Molecular Weight 95.53

  •  Beilstein/REAXYS Number 3591990

  •  EC Number 200-002-3

  •  MDL number MFCD00013026

  •  PubChem Substance ID 329823024

  •  NACRES NA.21

Purchase

Properties

Related Categories Biochemicals and Reagents, Chaotropic Agents, Denaturation More...
Quality Level   400
biological source   synthetic
Agency/Method   non-compendial
product line   PharmaGrade
form   powder
impurities   Endotoxin, microbial, and trace metals; tested
pH   (25 °C, 4.6 - 6/573 g/L)
mp   180-185 °C (lit.)
solubility   H2O: 6 M at 20 °C, clear, colorless
density   1.3 g/cm3 (lit.)
suitability   suitable for manufacturing use
foreign activity   Dnase and RNase; tested
SMILES string   Cl[H].NC(N)=N
InChI   1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChI key   PJJJBBJSCAKJQF-UHFFFAOYSA-N
Gene Information   human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Packaging

100 g in poly bottle

5, 25, 50 kg in poly drum

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Linkage

Enhanced Quality Product Documentation on PharmaGrade Guanidine Hydrochloride

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
MF4300000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles

Related Content

Enhanced Quality Program [VIDEO]

The Enhanced Quality Program is a quality management system that is used to differentiate products based on the required level of transparency, control and documentation support determined by the nee...

One Quality Policy [VIDEO]

Sigma-Aldrich maintains one quality policy on a global level to provide consistency in vision, maintained across all manufacturing and distribution sites so that the company on the whole is adhering ...

Quality Management Systems [VIDEO]

See how we combine the use of various Quality Management Systems to manage manufacturing and supply chain for our products, as well as ensure data integrity for information provided to customers via ...

Risk Management [VIDEO]

Our Quality Policy means that we are able to provide certain information to end customers based on a product’s Enhanced Quality level, and that information is limited to what we are able to guarantee...

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?