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PHG0007 SAFC

MOPS

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym: 3-(N-Morpholino)propanesulfonic acid, 4-Morpholinepropanesulfonic acid

  • CAS Number 1132-61-2

  • Empirical Formula (Hill Notation) C7H15NO4S

  • Molecular Weight 209.26

  •  Beilstein/REAXYS Number 1106776

  •  EC Number 214-478-5

  •  MDL number MFCD00006183

  •  PubChem Substance ID 329823025

  •  NACRES NA.21

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Properties

Related Categories Biochemicals and Reagents, Biological Buffers, Good’s Buffers, PharmaGrade Buffers
Quality Level   400
biological source   synthetic
grade   Non-Compendial
InChI Key   DVLFYONBTKHTER-UHFFFAOYSA-N
product line   PharmaGrade
assay   ≥99.5%
form   powder
application(s)   cell culture | mammalian: suitable
impurities   Endotoxin, microbial, and trace metals; tested
pH   2.5-4 (1 M in H2O)
useful pH range   6.5 - 7.9
pKa (25 °C)   7.2
λ   1 M in H2O
suitability   suitable for manufacturing use
foreign activity   Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Packaging

1 kg in poly bottle

10, 25 kg in poly drum

100 g in poly bottle

Application

MOPS is a biological buffer also referred to as a “Propane Sultone” buffer. The pKa of MOPS is 7.01 which make it an ideal candidate for medias and protein based buffer formulations to maintain a stable environment in solution. MOPS is considered to be non-toxic to culture cell lines and provides high-solution clarity.

MOPS is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream). MOPS based buffers are used in purification bioprocesses of antibodies, peptides, proteins and blood components.

Linkage

Enhanced Quality Product Documentation on PharmaGrade MOPS

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
QE9104530
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles

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Peer-Reviewed Papers
15

References

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