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  • PRS2499 - Anti-CIKS (ab1) antibody produced in rabbit

PRS2499 Sigma-Aldrich

Anti-CIKS (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-TRAF3 Interacting protein 2



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Gene Regulation and Expression, Antibodies to Transcription Regulators,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
species reactivity   human
mol wt   predicted mol wt 63 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   O43734
Gene Information   human ... TRAF3IP2(10758)


General description

CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is a cytoplasmic protein, that exists in the nucleus. It is also termed as Act1 (NF-κB activator 1) and TRAF3IP2 (TRAF3 interacting protein 2). The gene is located on chromosome 6q21.


a synthetic peptide corresponding to amino acids 554-568 of human CIKS.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is susceptible to various diseases like psoriasis and psoriatic arthritis. It is responsible for the cardiomyocyte growth, fibroblast migration and proliferation, promoted by aldosterone. It participates in the signaling function of IL-17 (interleukin) cytokine family. It can act as a transcriptional enhancer due to its presence in the nuclear compartment of airway epithelial cells.


The action of this antibody can be blocked using blocking peptide SBP2499.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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