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PZ0021 Sigma-Aldrich

Tigecycline hydrate

≥98% (HPLC)

Synonym: 9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tigecyclin, Tygacil

  • CAS Number 1229002-07-6

  • Empirical Formula (Hill Notation) C29H39N5O8 · xH2O

  • Molecular Weight 585.65 (anhydrous basis)

  •  PubChem Substance ID 329823688

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   PMPLAEFBZIFHAR-KXLOKULZSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -160 to 170°, c = 0.15 in methanol
color   off-white to yellow-brown
solubility   DMSO: ≥3 mg/mL (warmed)
originator   Pfizer
storage temp.   2-8°C

Description

Other Notes

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

air sensitive

Packaging

5, 25 mg in glass bottle

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Application

TIGECYCLINE HYDRATE has been used:
• for antibiotic susceptibility testing
• to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
• to evaluate its effects on the binding of fluoroquinolones to human serum albumin
• as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

Biochem/physiol Actions

Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

General description

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QI7619500

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Immunology Research

The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
Keywords: Antibiotics, Antifungals, Antivirals, Apoptosis, Bioactive small molecules, Cell signaling, Diabetes, Diseases, Immunology, Inflammation

Pfizer Compounds for Immunology

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Immunology

Peer-Reviewed Papers
15

References

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