PZ0149 Sigma-Aldrich


≥98% (HPLC)

Synonym: (S)-2-(3-(1-((4-Isopropylbenzyloxy)carbonyl)piperidin-3-yl)phenoxy)-2-methylpropanoic acid

  • CAS Number 702681-67-2

  • Empirical Formula (Hill Notation) C26H33NO5

  • Molecular Weight 439.54

  •  MDL number MFCD18452851

  •  PubChem Substance ID 329823734

  •  NACRES NA.77



Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -50 to -65°, c = 0.2 in methanol
mfr. no.   Pfizer®
color   white to off-white
solubility   DMSO: ≥30 mg/mL
originator   Pfizer
storage temp.   2-8°C
SMILES string   CC(C)c1ccc(COC(=O)N2CCC[C@H](C2)c3cccc(OC(C)(C)C(O)=O)c3)cc1
InChI   1S/C26H33NO5/c1-18(2)20-12-10-19(11-13-20)17-31-25(30)27-14-6-8-22(16-27)21-7-5-9-23(15-21)32-26(3,4)24(28)29/h5,7,9-13,15,18,22H,6,8,14,16-17H2,1-4H3,(H,28,29)/t22-/m1/s1



5, 25 mg in glass bottle

Biochem/physiol Actions

CP-868388 is a potent PPARα agonist with a Ki of 10.8 nM.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

This compound was developed by Pfizer for Gene Regulation research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pfizer is a registered trademark of Pfizer, Inc.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
UN 2811 6.1 / PGIII
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Nuclear Receptors (Non-Steroids)

The receptors for several classes of non-steroidal compounds, including retinoids, thyroid hormones and vitamin D, also act as ligand-dependent transcription factors. In addition, a large number of r...
Keywords: Absorption, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell proliferation, Clinical, Detoxification, Diabetes, Diseases, Gene expression, Hormones, Ligands, Lipid Metabolism, Metabolism, Metabolites, Obesity, Transcription, Transduction, Vitamins

Nuclear Receptors (PPARs)

Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid...
Keywords: Anti-inflammatory agents, Atomic absorption spectroscopy, Cancer, Cell proliferation, Clinical, Diabetes, Diseases, Gene expression, Hormones, Inflammation, Ligands, Lipid Metabolism, Metabolic Pathways, Metabolism, Obesity, Oxidations, RNA immunoprecipitation, Transcription, Vitamins

Pfizer Compounds for Gene Regulation

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Gene Regulation

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