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PZ0151 Sigma-Aldrich

PF-956980 hydrate

≥98% (HPLC)

Synonym: {(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-pyrrolidin-1-yl-methanone hydrate

  • Empirical Formula (Hill Notation) C18H26N6O · xH2O

  • Molecular Weight 342.44 (anhydrous basis)

  •  MDL number MFCD18452852

  •  PubChem Substance ID 329823736

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Diversification Ready Pharma-Developed Compounds,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +33 to +40°, c = 0.5 in methanol
mfr. no.   Pfizer®
color   white to off-white
solubility   DMSO: ≥50 mg/mL
originator   Pfizer
storage temp.   2-8°C
SMILES string   O.C[C@@H]1CCN(C[C@@H]1N(C)c2ncnc3[nH]ccc23)C(=O)N4CCCC4
InChI   1S/C18H26N6O.H2O/c1-13-6-10-24(18(25)23-8-3-4-9-23)11-15(13)22(2)17-14-5-7-19-16(14)20-12-21-17;/h5,7,12-13,15H,3-4,6,8-11H2,1-2H3,(H,19,20,21);1H2/t13-,15+;/m1./s1
InChI key   VZUKSTKLTSSYKP-PBCQUBLHSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pfizer is a registered trademark of Pfizer, Inc.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

PDGFR

Platelet-derived growth factor (PDGF) is a family of disulfide-bonded dimeric molecules of A-, B-, C- and D-polypeptide chains (PDGF-AA, -AB, -BB, -CC and -DD). PDGF isoforms stimulate proliferation,...
Keywords: Atomic absorption spectroscopy, Cell proliferation, Central Nervous System, Diseases, Gastrointestinal, Growth factors, Ligands, Phosphorylations, Solid state metathesis, Transcription, transformation

Pfizer Compounds for Kinase Phosphatase Biology

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Kinase Phosphatase Biology

VEGFR

The vascular endothelial growth factor receptor (VEGFR) family comprises in humans three endothelial cell (EC) specific tyrosine kinase receptors (VEGFR-1, VEGFR-2 and VEGFR-3). VEGFRs are the major ...
Keywords: Angiogenesis, Atomic absorption spectroscopy, Capillary electrophoresis, Cardiovascular, Growth factors, Ligands, Phosphorylations

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