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PZ0187 Sigma-Aldrich

Begacestat

≥98% (HPLC)

Synonym: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide, GSI-953

  • CAS Number 769169-27-9

  • Empirical Formula (Hill Notation) C9H8ClF6NO3S2

  • Molecular Weight 391.74

  •  MDL number MFCD18782675

  •  PubChem Substance ID 329823761

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Diversification Ready Pharma-Developed Compounds,
InChI Key   PSXOKXJMVRSARX-SCSAIBSYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥15 mg/mL
originator   Pfizer
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Begacestat (GSI-953) is a selective γ-secretase inhibitor that selectively inhibits cleavage of APP over Notch.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

Other Notes

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Pfizer Compounds for Neuroscience

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Neuroscience

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