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PZ0269 Sigma-Aldrich

PF-03049423

≥98% (HPLC)

Synonym: 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-pyrido[3,4-b]pyrazin-2(1H)-one hydrochloride, 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one hydrochloride, PF-5

  • CAS Number 402955-58-2

  • Empirical Formula (Hill Notation) C24H32N6O4 · xHCl

  • Molecular Weight 468.55 (free base basis)

  •  PubChem Substance ID 329823803

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 20 mg/mL, clear
originator   Pfizer
storage temp.   room temp
SMILES string   CCCOCCN1C2=C(C=NC(C3=CN=C(OC)C=C3)=C2)N=C(N4CCN(CCO)CC4)C1=O.C
InChI   1S/C24H32N6O4.CH4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31;/h4-5,15-17,31H,3,6-14H2,1-2H3;1H4
InChI key   BXMDZHBYGYPATN-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PF-03049423 is an orally active, brain penetrant phosphodiesterase 5 (PDE5) inihbitor.

Other Notes

This compound was developed by Pfizer for Cyclic Nucleotides research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Pfizer Compounds for Cyclic Nucleotides

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Cyclic Nucleotides

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