• USA Home
  • PZ0280 - CP-456773 sodium salt

EMAIL THIS PAGE TO A FRIEND
PZ0280 Sigma-Aldrich

CP-456773 sodium salt

≥98% (HPLC)

Synonym: CRID3, Cytokine release inhibitory drug 3, MCC950, N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

  • CAS Number 256373-96-3

  • Empirical Formula (Hill Notation) C20H23N2NaO5S

  • Molecular Weight 426.46

  •  PubChem Substance ID 329823808

  •  NACRES NA.77

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
mfr. no.   Pfizer®
color   white to beige
solubility   H2O: 20 mg/mL, clear
originator   Pfizer
storage temp.   room temp
SMILES string   CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
InChI   1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChI key   LFQQNXFKPNZRFT-UHFFFAOYSA-M

Description

Application

CP-456773 sodium salt has been used :
• In in vivo experiments to study the neuroprotective action of ketogenic diet.
• To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
• To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.

CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.

Other Notes

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Pfizer Compounds for Cytokines and Growth Factors

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Cytokines and Growth Factors

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?