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PZ0348 Sigma-Aldrich

NI-42

≥98% (HPLC)

Synonym: 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

  • CAS Number 1884640-99-6

  • Empirical Formula (Hill Notation) C18H15N3O3S

  • Molecular Weight 353.40

  •  MDL number MFCD30290161

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

NI-42 is a biased potent small molecule inhibitor of the bromodomain of the BRPF (bromodomain and PHD finger-containing) proteins, which are scaffolding proteins that assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family. NI-42 has an IC50 value of of 7.9 nM and is suitable for cellular and in vivo studies.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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