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Q1125 Sigma-Aldrich

Quinine hydrochloride dihydrate

  • CAS Number 6119-47-7

  • Empirical Formula (Hill Notation) C20H24N2O2 · HCl · 2H2O

  • Molecular Weight 396.91

  •  EC Number 205-001-1

  •  MDL number MFCD00078498

  •  PubChem Substance ID 57654577

  •  NACRES NA.77

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Properties

Related Categories Alkaloid, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic,
solubility   H2O: 0.25/5 g/mL, clear, colorless
Mode of action   enzyme | inhibits
antibiotic activity spectrum   parasites
SMILES string   O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
InChI   1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
InChI key   SGVZDMWHXVXUBY-HZQSTTLBSA-N

Description

General description

Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.

Application

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.

Biochem/physiol Actions

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.

Potassium channel blocker

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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