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Q1250 Sigma-Aldrich

Quinine hemisulfate salt monohydrate

synthetic, ≥90% (HPLC)

Synonym: Quinine sulfate (2:1) (salt) dihydrate

  • CAS Number 207671-44-1

  • Empirical Formula (Hill Notation) C20H24N2O2 · 0.5H2O4S · H2O

  • Molecular Weight 391.47

  •  Beilstein/REAXYS Number 6113937

  •  MDL number MFCD00150790

  •  PubChem Substance ID 57654578

  •  NACRES NA.77



Related Categories Alkaloid, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic,
Quality Level   100
biological source   synthetic
assay   ≥90% (HPLC)
mp   ~225 °C (dec.) (lit.)
solubility   H2O: slightly soluble 1.2 mg/mL
  ethanol: 8 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   parasites
originator   Bayer
SMILES string   O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
InChI   1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1



Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.


5, 10, 50 g in glass bottle

Biochem/physiol Actions

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Quinine has analgesic property.

Features and Benefits

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Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
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Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
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Peer-Reviewed Papers


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